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As an example, human SET7/9 has recently been reported to methylate Lys189 within the general transcription issue TAF10, leading to an increased affinity for RNA polymerase II and transcriptional activation of sure TAF10-dependent genes 37 SET7/9 has additionally been reported to methylate p53, rising the steadiness of this quick lived tumor-suppressor protein 38 These observations counsel that we should always not narrowly outline the SET-domain proteins as histone lysine methyltransferases but as an alternative call them protein lysine methyltransferases. |
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